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*UPDATE* HELP CURE Type 1 Diabetes

30-12-2008

Calling 1 million people with $25 to HELP CURE Type 1 Diabetes

“This research will attempt to
reverse established diabetes,
rather than simply introduce new
pumps or other types of new
equipment or drugs to delay the
onset of diabetic complications.
That is a cause for new hope
and a new vision for people who
already have diabetes.”
—Dr. Denise Faustman

Hello there! and thank you for your support,

I am no longer as closely involved with Dr. Faustmans lab as I could be sadly.  But If you wish to keep up with her and her team or wish to donate to her directly please the Faustmanlab.org

What is today on here page…..

Support the Faustman Lab
The research conducted by the Faustman Lab receives no Federal funding and is 100% supported by philanthropic individuals and foundations.
Your gift of any amount will support the Faustman Lab’s search for a type 1 diabetes cure. Make gift today.
How to Help
There are many ways that you can support the work of the Faustman Lab. Making an outright gift online using a credit card is the most convenient. If your prefer to make a donation via check, you can do so by making your check out to “Massachusetts General Hospital – Faustman Research” and mailing it to:
MGH Development Office
Attn: Jocelyn Hoey
165 Cambridge Street, Suite 600
Boston, MA 02114
You can also run a fundraiser or other event to benefit the Faustman Lab or help spread the word about our work.
Cure Diabetes Now Fund
To support the Faustman Lab’s work, the Cure Diabetes Now Fund was established. The Cure Diabetes Now Fund is operated by Massachusetts General Hospital, an institution with 501c3, non-profit status. Your gift to the fund is tax-deductible to the extent provided by law.
Support the Clinical Trials
The Faustman Lab is now conducting human clinical trials with BCG, a widely-used, inexpensive generic drug that may help to remove the “bad” cells that cause type 1 diabetes. These clinical trials are unique because they are focused on people living with diabetes, as opposed to only those who have been newly-diagnosed. Most importantly, the goal of Dr. Faustman’s clinical trials is to develop a cure for diabetes, not just manage the condition.
Phase I of the clinical trials began in January 2008 and is fully funded. With your support, Phase II will begin in late 2009. Phase II will last three years and will cost approximately $25 million. At least $8.4 million will be needed by late 2009 to initiate the first year of Phase II.”

Now Back to the old post that was always here with some more info……….



Denise Faustman, MD, PhD, has spent the last decade researching a cure for type 1 diabetes. This
work led her to discover a novel way to treat type 1 diabetes, accomplishing for the f rst time ever the
permanent reversal of established diabetes in mice.Dr. Faustman is expanding this promising
research to human applications and will hopefully one day cure type 1 diabetes.
Dr. Faustman is the director of the Immunobiology Laboratory at Massachusetts General
Hospital (MGH) and an associate professor of medicine at Harvard Medical School. Dr. Faustman
became an independent investigator at MGH and arvard Medical School in 1987. She completed her
internship, residency, and fellowships in Internal Medicine and Endocrinology at MGH.  She is also
a member of the American Association for the Advancement of Science and serves as a frequent member of the Institute of Medicine.
One of the most exciting things about   Dr. Faustman’s research is that it makes use of
a widely-used, inexpensive generic drug: BCG. Typically, generic drugs offer an affordable
opportunity to expand the reach of treatment.  The use of a generic drug with a well-
documented safety record like BCG also allows Dr. Faustman’s research to move quickly — in
clinical trial terms — through human testing.  If the BCG therapy is effective, Dr. Faustman
and her colleagues hope to bring an inexpensive treatment to many patients who will benefit
tremendously.
For more information on Dr. Faustman’s
research, please visit www.faustmanlab.org.
support-a-cure-large-PDF



All they need is money. Does anyone have enough money and care enough about curing diabetes to fund this research? Do you?

Even if you have type 1 diabetes, you almost certainly still have some of your beta cells. If your body stops killing them, they will replicate and produce insulin — and then you will possibly have a cure!!

A sincere thanks to all who have contributed to this!

Mr. Paglia Great response!! Thanks!!

“It’s about the first research I’ve seen that’s gotten me excited,” Paglia said of the work being done by Dr. Denise Faustman at Massachusetts General Hospital.

The immunologist, whose work led to the first-ever cure of type 1 diabetes in mice, needs money for research that has expanded into human trials.

So Paglia, owner of Acupuncture Health Center in Bellingham, is launching a fundraiser Saturday. For $20, participants can get an hour-long acupuncture session that would normally cost $110.

All the proceeds will go to Faustman’s research.

“People have been really, really pumped up about it,” Paglia said of the fundraising effort.

Paglia plans to have a few more fundraisers this year, with the idea of donating at least $1,400 to Faustman’s research – a goal he believes will be achieved easily. Read More here....

Again thank you and best to you all!

More than 177 million people had been diagnosed with diabetes world wide; by 2025, it could be up to 300 million if nothing is done.
There are 23.6 million people living with diabetes in the United States alone, a terrifying 8% of the American population. From 2005 to 2007, the rate of diabetes in the U.S. went up by 13.5%.
Only 10% of diabetes cases are type 1.
“There is a growing incidence of type 2 diabetes in children and young people from high-risk populations,” the Canadian Diabetes Association says. “Recent data suggests an American child born in 2000 stands a one in three chance of being diagnosed with diabetes in his or her lifetime.”
It’s very closely related to the rising obesity rates, but is also affected by factors like the ageing populations and mainly, poor diet and nutrition.

Thank you Allie for this post!  I cannot say anything better than her….:)

Why has the JDRF denied funding to Dr. Faustman and her research to cure Type 1 diabetes? Phase 1 has become the burden of proof that the “Faustman Hypothesis” is the frontiers we must explore to cure type 1 diabetes and other autoimmune diseases. JDRF – if you’re not part of the solution you are part of the problem! Here’s my call to action: Phase 2 of Dr. Faustman’s human trials are estimated to cost $25 million. If 1 million people watching this video have the wherewithal to donate $25 to Dr. Faustman’s human trials at MGH – the cure for millions is unstoppable! Do you have $25 to make a dream come true? Please donate to Dr. Faustman’s research

In 1921 the discovery of insulin gave people with insulin-dependent (type 1) diabetes new hope. No longer would they succumb to the demise of lethal blood glucose levels. A new treatment promised a reduction of glucose levels that granted an extension of life with diabetes. Over time the treatment was perfected with self glucose testing and more advanced methods of delivering insulin. Over 80 years later – the world of diabetes treatment continues to be: check sugar, treat and repeat. Is this really as good as it gets?

Throughout the evolution of diabetes treatment the hunt for a cure was never at rest. Within the last few years the hot pursuit for a diabetes cure got especially heated when Dr. Denise Faustman hit the scene.

When Dr. Faustman revealed her ground-breaking discovery in 2001, most of the diabetes community turned their noses up. Dr. Faustman said she had cured diabetic mice by getting them to regenerate their insulin-producing cells (beta cells). Today Faustman dismisses the initial doubt by looking at the bright-side. She remarks “a lot of groups are working on this now,”. “If imitation is the best form of flattery, then I’m flattered.”

Having been published in national newspapers like The New York Times, The Boston Globe and the Wall Street Journal, Dr. Faustman’s research continues to gain recognition. Scientific journals like Scientific American and The New Scientist and magazines like US News and Newsweek have written about her research. Even The National Institute of Health (NIH) recognizes Dr. Faustman’s research to reverse autoimmune diabetes. Even Oprah Magazine recognized Dr. Faustman as the #1 women scientist of the year in 2005.

To correct the autoimmune attack, Faustman injected mice with a cocktail that made their bodies produce a signaling chemical called TNF-alpha. This compound destroyed the defective T-cells that mistakenly destroyed islets. When a surgeon implanted islets on the kidneys of each mouse, the transplants could take root, make insulin and restore normal blood sugar. To eliminate the problem of the bad T-cells returning, Faustman borrowed an idea from the transplant specialists, who have found that liver or spleen cells can “reeducate” a recipient’s immune system to treat the new cells as good cells.

Until recently, it was taken for granted that once the beta cells are lost, they cannot grow back. In March 2006, three separate scientific studies (funded by the Juvenile Diabetes Research Foundation) confirmed that they had repeated Faustman’s protocols and reproduced her most important result: it is possible to stop the mistaken T-cell attack and when you do, the animals recover normal function. “The results are fantastic, coming from these groups, which were each paid $1 million to spend three years showing that I was wrong,” Dr/ Faist,am remarks. “I mean, they were all funded by the JDRF.”

With Dr. Faustman’s revolutionary research now completing Phase 1, and scheduled to begin Phase 2 in the summer of 2009 – the hope for a diabetes cure is closer than ever. No longer will curing diabetes be a pipedream for the future. Dr. Faustman’s research will become the treatment for a diabetes cure today.

March 13, 2008

Emily Parker

http://harvardscience.harvard.edu/medicine-health/articles/initial-human-trial-type-1-diabetes-treatment-begun

Massachusetts General Hospital

Scientists at the Massachusetts General Hospital (MGH) have initiated a phase 1 clinical trial to reverse type 1 diabetes. The trial is exploring whether the promising results from the laboratory of Denise Faustman, Associate Professor of Medicine at Harvard Medical School, can be applied in human diabetes.

A phase 1 trial is usually designed to determine the safety, side effects, and dosage range of a treatment, rather than its usefulness. If the proposed treatment is found to be safe, then researchers may initiate a phase II trial, to test for efficacy, in a relatively small group of subjects.

In previous studies Faustman has demonstrated that mice can be cured of a form of diabetes closely resembling type 1 in humans. Those studies used Bacillus Calmette-Guerin (BCG), a common tuberculosis vaccine, to deplete the abnormal immune cells that attack and destroy the insulin producing cells of the pancreas. The first step in the human study, which is currently enrolling volunteers, is to determine whether the same strategy using BCG vaccination can be used to modify the abnormal autoimmune cells present in type 1, or so-called “juvenile onset” diabetes.

David M. Nathan, MD, director of the MGH Diabetes Center, who is leading the human study at MGH, cautions that this “this is the very first step in what is likely to be a long process in achieving a cure. We first need to determine whether the abnormal autoimmune cells that underlie type 1 diabetes can be knocked out with BCG vaccination, as occurred in the mouse studies.”

“We are pleased to be starting human clinical trials,” Faustman said. “Human trials take time, but we are making the step from curing diabetes in mice to determining whether it will work in men and women with diabetes.”

Type 1 diabetes, which usually begins during childhood or adolescence, is triggered when the  immune system attacks and destroys the insulin-producing cells in the pancreas. In the absence of insulin, which is necessary for sugar and other nutrients to enter cells, blood sugar levels rise and can cause a variety of severe complications, including kidney failure, loss of vision, amputations, heart disease, and strokes.

……Cut for shorter length,,,,,,,. Thus, a cure for diabetes has been highly sought after and has attracted much research interest.

The clinical trial is using the BCG vaccine because it causes a low-grade inflammatory reaction, which in the mouse model of autoimmune diabetes lead to the destruction of the abnormal autoimmune cells. It is a particularly attractive candidate vaccine because it has been used safely for nearly 80 years as a tuberculosis vaccine.

The Phase I trial is being supported largely through direct and fund raising support from the Iacocca Foundation, and through support from other donors and the Massachusetts General Hospital.  The Iacocca Foundation was founded by Lee Iacocca and his family in 1984 to fund innovative approaches to a potential cure for diabetes.

Prospective trial participants should contact the MGH Diabetes Center at 617-726-1847.

[HarvardScience does not have any additional information about this story.]

Please donate to Dr. Faustman’s Laboratory to fund Phase 2 human trials to cure diabetes.

Some more links and info on this cure and common adverse reactions to the new dna insulin…….

*NEW*Announcing The Cure Trials begin!!!!(JDRF) Embezzlement *Plus*
Permalink:
alliesvoice.com/2008/08/14/allies-voice-calling-1-million-people-with-25-to-help-cure-type-1-diabetes.aspx

Diabetes Search engine (Helps find a cure as you search)
A bit more info found……

http://www.healthcentral.com/diabetes/c/651280/52532/innovative-mice
http://www.massgeneral.org/give/giftatwork/diabetes.aspx
http://www.inspire.com/groups/us-news-health/discussion/a-diabetes-cure-in-clinical-trials/

http://www.diabeteshealth.com/read/2008/12/17/715.html

http://nose1.com/hero/index.cfm/1/59/1

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6 Comments leave one →
  1. Amy permalink
    28-10-2008 08:24

    Is it as simple as giving my child the TB Vaccine? Sorry such a simple question. Amy

  2. 28-10-2008 16:54

    Hello Amy,

    Simple as that is correct.
    Yet there are factors that we are aware of,
    1. it does involve a larger amount than a dose for Malaria.
    2. Each Diabetic has varied doses
    3.And then there will be other factors found within the trial itself, for mice it worked but people talkback 🙂

  3. Allen permalink
    27-11-2008 23:07

    I’d like to see a response from JDRF to go with this. I’m not saying you need to do that to be ‘fair.’ But I don’t know you, whereas JDRF is a known to me as a good organization so I would like to see their response included with your criticism.

  4. 27-11-2008 23:52

    Greetings Allen, Great wish , I wish I could help you with such, but they remain silent on this issue.

    Allie Beatty, is not stupid. In fact, she’s one of the brightest and most well read individuals on this subject. She’s so convinced of Dr. Faustman’s research, that she and I have volunteered for the human trials. I strongly encourage you to hear her out: http://www.alliesvoice.com . I can think of no one more dedicated to finding a solution to this wretched disease than her. If you’re contributing to the JDRF, I would encourage you to stop and think about this… really hard.

    If you care enough to right a wrong, I strongly urge you to forward this to all your friends, diabetic or not, simply to make them aware that all is not as it seems when it comes to charitable organizations. If you would like to support Dr. Faustman’s research, go here: http://www.faustmanlab.org/research.html and click the support link at the bottom.

    Meanwhile, you can write the JDRF here: http://www.jdrf.org/index.cfm?page_id=101007
    And ask them why they can’t part with a tiny fraction of their annual outlay to support Dr. Faustman’s research. Always remember this, so called support organizations whose existence is dependent on sympathetic followers, DON’T WANT a solution to the problem that fostered them in the first place… that would eliminate their justification for existence. Wouldn’t it?

    If you would like to learn more, I suggest you read this: Wikipedia page on T1DM

  5. Aine Maire Ui Chuirc permalink
    24-12-2008 08:57

    *Note*
    Thank you Aine Maire this is nice to see their response.
    Great Mom’s do amazing things for their children!
    Her Original Post…..

    Hi Guys,

    I got your comments across here in Ireland and would like to add that I also completely believe that Dr Faustman will cure diabetes in my young son. When I heard that the JDRF were not supporting her, I asked them why and this is the response…

    Aine Maire

    *************

    Thank you for contacting the Juvenile Diabetes Research Foundation International (JDRF). We’re glad you find the research information posted on the JDRF web site to be helpful. We also appreciate your inquiry regarding the research of Dr. Faustman and her colleagues at Massachusetts General Hospital involving beta cell regeneration and autoimmune regulation.

    Beta cell regeneration and autoimmune regulation are two of the major strategic areas of research focus for JDRF — areas in which we believe we can make significant progress towards developing cure therapeutics in the coming years. Over the past few years, we have funded a significant number of scientific investigations in these areas. In fact, since 1997, JDRF has provided over $500,000 of research support to Dr. Faustman and her colleagues at Massachusetts General, including support of work that contributed to her published findings.

    While JDRF has not provided funding for the trials Dr. Faustman is currently conducting, she has been able to procure funding for her research studies from other sources, allowing JDRF to use its funds to support other projects involving beta cell regeneration and autoimmune regulation that may eventually contribute to a cure.

    While we’re not funding Dr. Faustman specifically, JDRF has made a large investment in autoimmunity and regeneration research. In FY2007, JDRF provided a combined $53 million to fund research in these areas. A clear indication that we are having an impact is the recent growth in the number of compounds and products that already are in human trials. Right now JDRF has 20+ clinical trials in progress that are testing ways to block the autoimmune attack.

    I hope you find this information helpful, and please let me know if I can answer any more questions.

    Sincerely,

    Gary Feit
    Manager, Public Information
    Juvenile Diabetes Research Foundation
    120 Wall St. 19th Floor
    New York, NY 10005
    [Omitted for confidentiality]

  6. 10-1-2009 21:39

    Denise Faustman is an individual researcher. She was a physician, treating diabetics. Then, she got a PhD to go into autoimmune disease research. She is on the faculty of Harvard Medical School.

    JDRF is a foundation, that provides information for T1s and raises large amounts of money to give out in research grants. They are an advocacy group for T1.

    Faustman started out on the usual track with research. She trained with the guy who was considered the pioneer in islet cell transplants. But, she soon decided that there really was no point to islet cell tranplants when the immune system of a T1 would just attack and destroy them and it required the patient to be on nasty immunosuppressant drugs for life. So, she started working on the underlying problem that causes T1.

    She did some experiments with mice who had genetic, end-stage T1. She gave them a drug to ratchet up their immune system, because she believes the reason why people have autoimmune disease is because their immune systems let the protective cells of the immune system — that normally protect us from disease agents — like bacteria, viruses — attack the person’s own tissues and those T cells are not screened out by the person’s own immune system. Our immune systems have a complex system of producing tons of these T cells and then our bodies have to train them to recognize our own tissues and not attack them, since these cells’ functions is to destroy. This is a pretty complex system and I don’t understand all the details. But I have read that the vast majority of these fighter T cells do not pass our own body’s screening process and are killed off by our bodies and never allowed to circulate — over 90%, I think. In a person with autoimmune disease, some slip by and are able to then attack the person’s own tissues.

    The conventional way of thinking (the opposite of Faustman) about this with diabetes researchers was to suppress the immune system, because they looked at it as an over-active immune system and they thought by suppressing it, they could stop T1. That’s still going on with the vast majority of drugs that are being tested on T1s. But this has lots of side effects and a suppressed immune system is not a good thing. Many researchers are still working on islet cell transplants.

    Faustman’s experiments on these diabetic mice worked — they were cured. They started making their own insulin again, once the immune system problem was resolved. There’s more to the experiments, but this is the gist. Faustman published the work and it got lots of attention. Other researchers were cynical and didn’t believe her results. Faustman applied to JDRF for funding, since this was so promising. This particular breed of diabetic mice and humans have very similar types of diabetes, so it was hoped that it might work in humans too. Faustman was turned down. Not only was she turned down, but JDRF funded 3 other labs with millions of dollars to try to prove her wrong. There was a smear/whispering campaign against Faustman among some in the diabetes research community. They wrote letters to newspapers putting her down and when the newspapers refused to publish the letter, they passed it around on email lists.

    Eventually, the people who were funded to prove her wrong got similar results. Their cure rates weren’t as high, but there could be a number of reasons for that. They still did show that her work does have promise. Even then, JDRF never funded her. In their news sections, they won’t even list her recent work when it’s published. She’s still getting major publications in the most prestigious scientific journals. She’s never invited to the conferences that JDRF hosts for diabetes researchers. She’s been shut out. The same people who sit on the JDRF funding boards, tend to sit on the gov’t research funding boards, like NIH. She’s not getting grants from them either. In the meantime, her work is carefully and methodically continuing. She’s said that she knows she’s risked her very successful career to pursue this line of research. She’s had to go to private benefactors for funding. All she ever did “wrong” was to get results that were different from how other researchers thought diabetes worked. I thought researchers were supposed to follow different lines of inquiry and.. you know… research.

    I’ve watched lots of interviews with Faustman and she never trashes JDRF. She just goes about her own work. She has to spend time raising money, since she’s been shut out of the avenues open to every other researcher out there. She’s now trying to transfer the mouse experiments to humans and she’s doing FDA-approved clinical trails. She’s using a generic drug, so there’s no money to made by the pharmaceutical companies. So, she’s pretty much fighting this fight on her own.

    That is what all the controversy is about — that she came up with results that were probably the most promising in all of diabetes research and for whatever reason, it upset the rest of the diabetes research community.

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